Hippocampal Dendritic Spines Modifications Induced by Perinatal Asphyxia

Hippocampal Dendritic Spines Modifications Induced by Perinatal Asphyxia

Perinatal asphyxia (PA) affects the synaptic function and morphological organization. In previous works, we have shown neuronal and synaptic changes in rat neostriatum subjected to hypoxia leading to long-term ubi-protein accumulation. Since F-actin is highly concentrated in dendritic spines, modifications in its organization could be related with alterations induced by hypoxia in the central n...

Hippocampal Dendritic Spines Are Segregated Depending on Their Actin Polymerization.

Dendritic spines are mushroom-shaped protrusions of the postsynaptic membrane. Spines receive the majority of glutamatergic synaptic inputs. Their morphology, dynamics, and density have been related to synaptic plasticity and learning. The main determinant of spine shape is filamentous actin. Using FRAP, we have reexamined the actin dynamics of individual spines from pyramidal hippocampal neuro...

Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons.

The spine apparatus is an essential component of dendritic spines of cortical and hippocampal neurons, yet its functions are still enigmatic. Synaptopodin (SP), an actin-binding protein, is tightly associated with the spine apparatus and it may play a role in synaptic plasticity, but it has not yet been linked mechanistically to synaptic functions. We studied endogenous and transfected SP in de...

Homeostasis of dendritic spines in hippocampal CA1 cells

Comparison of hippocampal dendritic spines in culture and in brain.

We have quantified hippocampal spine structure at the light and ultrastructural levels in cell cultures approximately 1- 3 weeks old and in the brains of rodents 5 and 21 d old. The number of spines bearing synapses increases with age in cultures and in brain, but the structures are similar in both. In culture, about half of the synapses are formed on spines and the remainder are formed on dend...